Submucosal gland mucus strand velocity is decreased in chronic rhinosinusitis.

ABSTRACT:

Background

Chronic rhinosinusitis (CRS) may be initiated by innately impaired host defense mechanisms that predispose the upper airways to infection. Recent evidence suggests tethering of submucosal gland mucus strands represents an inciting event within cystic fibrosis (CF) airways, occurring prior to onset of chronic infection. Submucosal gland hypertrophy and defective mucociliary clearance (MCC) are present in actively inflamed sinuses, but mucus strand velocity may also be affected as a secondary event, further contributing to chronic disease. The objective of this study is to assess whether mucus strand velocity is decreased in patients with CRS.

Methods

Mucosal explants from patients with and without CRS were submerged in Ringer's solution mixed with fluorescent nanos

SUBMITTER: Tipirneni KE 

PROVIDER: S-EPMC6520985 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature