Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer.

ABSTRACT: Background: Colorectal cancer (CRC) is a highly devastating cancer. Ca²⁺-dependent channels are now considered key regulators of tumor progression. In this study, we aimed to investigate the association of non-voltage gated Ca²⁺ channels and Ca²⁺-dependent potassium channels (KCa) with CRC using the transcriptional profile of their genes. Methods: We selected a total of 35 genes covering KCa channels KCNN1-4, KCNMA1 and their subunits KCNMB1-4, endoplasmic reticulum (ER) calcium sensors STIM1 and STIM2, Ca²⁺ channels ORAI1-3 and the family of cation channels TRP (TRPC1-7, TRPA1, TRPV1/2,4-6 and

SUBMITTER: Ibrahim S 

PROVIDER: S-EPMC6521016 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature