Anti-Obesity Effects of Tocotrienols and Bran in High-Fat Diet-Treated Mice.

ABSTRACT: Obesity is a serious public health issue in developed countries, and is known to increase the risk of several diseases such as diabetes, cardiovascular events and arteriosclerosis. These phenomena are closely correlated with oxidative damage. Recently, several lines of evidence have demonstrated that neurodegenerative diseases such as Alzheimer's and Parkinson's are also related to oxidative damage. To clarify the relationship between obesity and oxidative brain injury, we investigated brain antioxidant networks in high-fat (HF) diet-treated mice in the presence or absence of tocotrienols (T3s) and bran. Co-treatment with T3s and bran significantly inhibited bodyweight gain in HF diet-treated mice. Serum and cortex T3 levels, and brain antioxidant enzyme activities and protein expressions

SUBMITTER: Fukui K 

PROVIDER: S-EPMC6521046 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature