Altercrasins A⁻E, Decalin Derivatives, from a Sea-Urchin-Derived Alternaria sp.: Isolation and Structural Analysis Including Stereochemistry.

ABSTRACT: In order to find out the seeds of antitumor agents, we focused on potential bioactive materials from marine-derived microorganisms. Marine products include a number of compounds with unique structures, some of which may exhibit unusual bioactivities. As a part of this study, we studied metabolites of a strain of Alternaria sp. OUPS-117D-1 originally derived from the sea urchin Anthocidaris crassispina, and isolated five new decalin derivatives, altercrasins A-E (1-5). The absolute stereostructure of altercrasins A (1) had been decided by chemical transformation and the modified Mosher's method. In this study, four decalin derivatives, altercrasins B-E (2-5) were purified by silica gel chromatography, and reversed phase high-performance liquid chromatography (RP HPLC), and their structures

SUBMITTER: Yamada T 

PROVIDER: S-EPMC6521173 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature