Evaluation of Phage Therapy in the Context of Enterococcus faecalis and Its Associated Diseases.

ABSTRACT: Bacteriophages (phages) or bacterial viruses have been proposed as natural antimicrobial agents to fight against antibiotic-resistant bacteria associated with human infections. Enterococcus faecalis is a gut commensal, which is occasionally found in the mouth and vaginal tract, and does not usually cause clinical problems. However, it can spread to other areas of the body and cause life-threatening infections, such as septicemia, endocarditis, or meningitis, in immunocompromised hosts. Although E. faecalis phage cocktails are not commercially available within the EU or USA, there is an accumulated evidence from in vitro and in vivo studies that have shown phage efficacy, which supports the idea of applying phage therapy to overcome infections associated with E. faecalis. In this review, we

SUBMITTER: Bolocan AS 

PROVIDER: S-EPMC6521178 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature