Genetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population.

ABSTRACT: Despite classical environmental risk factors like tobacco, alcohol or viral infection, not all individuals develop head and neck cancer. Therefore, identification of the genetic susceptibility produced by single nucleotide polymorphisms (SNPs) is an important task. A total of 296 human papillomavirus negative head and neck cancer (HNC) patients (126 laryngeal, 100 pharyngeal and 70 oral cavity) were included in the study, involving 29 candidate SNPs in genes within important carcinogenic pathways (oncogenesis and tumour suppression, DNA repair, inflammation, oxidation and apoptosis). Genotyping was performed using TaqMan probes or restriction fragment length assays in peripheral blood DNA. In addition, 259 paired controls were also evaluated with the same risk factors for each specific loc

SUBMITTER: Fernandez-Mateos J 

PROVIDER: S-EPMC6521206 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature