Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1.

ABSTRACT: Alzheimer's disease (AD) is reportedly associated with the accumulation of calcium ions (Ca²⁺), and this accumulation is responsible for the phosphorylation of tau. Although several lines of evidence demonstrate the above phenomenon, the inherent mechanisms remain unknown. Using APP/PS1 Tg mice and neuroblastoma (N)2a cells as in vivo and in vitro experimental models, we observed that Ca²⁺ stimulated the phosphorylation of tau by activating microsomal PGE synthase 1 (mPGES1) in a prostaglandin (PG) E₂-dependent EP receptor-activating manner. Specifically, the highly accumulated Ca²⁺ stimulated the expression of mPGES1 and the synthesis of PGE₂. Treatment with the inhibitor of Ca²⁺ transporter, NMDAR, attenuated

SUBMITTER: Cao LL 

PROVIDER: S-EPMC6521221 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature