Rstoolbox - a Python library for large-scale analysis of computational protein design data and structural bioinformatics.

ABSTRACT:

Background

Large-scale datasets of protein structures and sequences are becoming ubiquitous in many domains of biological research. Experimental approaches and computational modelling methods are generating biological data at an unprecedented rate. The detailed analysis of structure-sequence relationships is critical to unveil governing principles of protein folding, stability and function. Computational protein design (CPD) has emerged as an important structure-based approach to engineer proteins for novel functions. Generally, CPD workflows rely on the generation of large numbers of structural models to search for the optimal structure-sequence configurations. As such, an important step of the CPD process is the selection of a small subset of sequences to be experimentally charac

SUBMITTER: Bonet J 

PROVIDER: S-EPMC6521408 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature