Balancing sensitivity and specificity in distinguishing TCR groups by CDR sequence similarity.

ABSTRACT:

Background

Repertoire sequencing is enabling deep explorations into the cellular immune response, including the characterization of commonalities and differences among T cell receptor (TCR) repertoires from different individuals, pathologies, and antigen specificities. In seeking to understand the generality of patterns observed in different groups of TCRs, it is necessary to balance how well each pattern represents the diversity among TCRs from one group (sensitivity) vs. how many TCRs from other groups it also represents (specificity). The variable complementarity determining regions (CDRs), particularly the third CDRs (CDR3s) interact with major histocompatibility complex (MHC)-presented epitopes from putative antigens, and thus encode the determinants of recognition.

Results

SUBMITTER: Thakkar N 

PROVIDER: S-EPMC6521430 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature