Temporal progression of gene regulation of peripheral white blood cells explains gender dimorphism of critically ill patients after trauma.

ABSTRACT:

Background

The immune response of the critically ill after severe trauma is sex-specific and may explain the different progression of the disease. This may be explained by a different gene regulatory program of their peripheral immune cells. We investigated the progression of the transcription profiles of peripheral immune cells of the patients to elucidate their distinct physiological response and clinical course.

Methods

We compared transcription profiles of whole blood of male and female patients from a larger longitudinal study of critically ill patients after trauma. We developed a statistical analysis pipeline that synchronized the time lapse of the profiles based on the temporal severity score of each patient.

Results

This enabled to categorize the temporal pro

SUBMITTER: Kolte A 

PROVIDER: S-EPMC6521436 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature