Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer.

ABSTRACT:

Objective

Peptic ulcer disease is a condition in which an important role has infection with H. pylori. The most common complication of peptic ulcer is bleeding. The presence of H. pylori triggers local and systemic cytokine signaling which may affect processes such as healing, gastric or duodenal rupture, and carcinogenesis. In this study, we examined the concentrations of IL-1β, IL-6, IL-10, TNF, TGF-β and IL-17A in serum by enzyme immunoassay and their mRNA expressions in periulcer biopsies obtained from patients with bleeding peptic ulcer by means of real-time-PCR.

Results

We have shown that pro-inflammatory IL-6 and TNF concentrations in serum were significantly higher in patients who were infected with H. pylori, while the concentrations of TGF-β and IL-17A were signifi

SUBMITTER: Milic L 

PROVIDER: S-EPMC6521506 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature