Positive/retained SDHB immunostaining in renal cell carcinomas associated to germline SDHB-deficiency: case report.

ABSTRACT:

Background

According to WHO, succinate dehydrogenase (SDH)-deficient renal cell carcinoma is characterized by negative immunostaining for SDHB, which remains positive in non-tumor tissue despite germline mutations in the SDHB gene. We now report a patient with a SDHB mutation, c.166_170del (p.Pro56Tyrfs*5) who developed renal cell carcinomas with characteristic morphological features of SDH-deficient renal cell carcinoma but had positive SDHB immunostaining.

Case presentation

Within a 6-year period, the patient developed two different renal cell carcinomas, which had characteristic morphological features of SDH-deficient renal cell carcinoma (uniform cells characteristically displaying eosinophilic granular material intermixed with fewer cells exhibiting clear intracytoplasm

SUBMITTER: Ugarte-Camara M 

PROVIDER: S-EPMC6521540 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature