Rapid phenotypic evolution in multidrug-resistant Klebsiella pneumoniae hospital outbreak strains.

ABSTRACT: Carbapenem-resistant Klebsiella pneumoniae (CRKP) increasingly cause high-mortality outbreaks in hospital settings globally. Following a patient fatality at a hospital in Beijing due to a blaKPC-2-positive CRKP infection, close monitoring was put in place over the course of 14 months to characterize all blaKPC-2-positive CRKP in circulation in the hospital. Whole genome sequences were generated for 100 isolates from blaKPC-2-positive isolates from infected patients, carriers and the hospital environment. Phylogenetic analyses identified a closely related cluster of 82 sequence type 11 (ST11) isolates circulating in the hospital for at least a year prior to admission of the index patient. The majority of inferred transmissions for these isolates involved patients in intensive care units. Wh

SUBMITTER: van Dorp L 

PROVIDER: S-EPMC6521586 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature