Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes.

ABSTRACT:

Background

Dyslipidemias have increased during the last decades in children.

Aim

The objective of this study was to analyze the influence of different polymorphisms in plasma triglyceride levels of children following a dietary treatment with plant sterols.

Design

A randomized, double-blind, crossover, controlled clinical trial was carried out in 26 children (16 women).

Materials and methods

Commercial milk, with 2.24 g sterols, was ingested daily during 3 weeks , and the same amount of kimmed milk without sterols, during the 3 week placebo phase. Both phases were separated by a washout period of 2 weeks. At the beginning and end of each phase, blood draws were performed.

Results

Apolipoprotein A5 Ser19Trp (P = 0.002), peroxisome proliferator-activ

SUBMITTER: San Mauro Martin I 

PROVIDER: S-EPMC6521671 | biostudies-literature | 2019 May-Aug

REPOSITORIES: biostudies-literature