Reproducibility of nasal allergen challenge responses in adults with allergic rhinitis.

ABSTRACT:

Background

Allergic rhinitis is characterized by nasal inflammation in response to allergen exposure. Nasal allergen challenges are used in clinical trials evaluating drug effects. Reproducibility of nasal secretion cytokine responses and physiological measurements are needed to determine the optimum measurements and power calculations for future studies. We have investigated the reproducibility of nasal cytokine measurements, using ready-to-use polyvinyl acetate sponges to collect nasal secretions, and measurements of nasal physiological responses.

Methods

Twelve subjects with allergic rhinitis and no history of respiratory disease, and 12 subjects with asthma and allergic rhinitis underwent a nasal allergen challenge. This was repeated at 7-14 days later.

Results

Th

SUBMITTER: Pantin CT 

PROVIDER: S-EPMC6521845 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature