Role of efavirenz plasma concentrations on long-term HIV suppression and immune restoration in HIV-infected children.

ABSTRACT:

Background

To access the long term relationship between efavirenz plasma concentrations and evolution of HIV RNA loads and CD4 cell counts in children.

Methods

Retrospective analysis of data from HIV-infected children on first line efavirenz-containing regimen. A population pharmacokinetic-pharmacodynamic (PK-PD) model was developed to describe the evolution of HIV RNA load and CD4 cell count (efficacy outcomes) in relation to efavirenz plasma concentration. Individual CYP2B6 516 G>T genotype data were not available for this analysis. A score (ISEFV) quantifying the effect of efavirenz concentrations on the long-term HIV replication was calculated from efavirenz concentrations and PD parameters and, a value of ISEFV below which HIV replication is likely not suppressed was de

SUBMITTER: Homkham N 

PROVIDER: S-EPMC6521995 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature