A multicentre retrospective cohort study of ovarian germ cell tumours: Evidence for chemotherapy de-escalation and alignment of paediatric and adult practice.

ABSTRACT:

Background

Adult guidelines recommend BEP (bleomycin, etoposide, cisplatin) for all ovarian germ cell tumours, causing debilitating toxicities in young patients who will survive long term. Paediatricians successfully reduce toxicities by using lower bleomycin doses and substituting carboplatin for cisplatin, while testicular and paediatric immature teratomas (ITs) are safely managed with surgery alone.

Aim

The aim was to determine whether reduced-toxicity treatment could rationally be extended to patients older than 18 years.

Methods

Multicentre cohort study was carried out in four large UK cancer centres over 12 years.

Results

One hundred thirty-eight patients were enrolled. Overall survival was 93%, and event-free survival (EFS) was 72%. Neoadjuvant/adjuvant

SUBMITTER: Newton C 

PROVIDER: S-EPMC6522056 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature