Melanoma-Induced Reprogramming of Schwann Cell Signaling Aids Tumor Growth.

ABSTRACT: The tumor microenvironment has been compared with a nonhealing wound involving a complex interaction between multiple cell types. Schwann cells, the key regulators of peripheral nerve repair, have recently been shown to directly affect nonneural wound healing. Their role in cancer progression, however, has been largely limited to neuropathic pain and perineural invasion. In this study, we showed that melanoma activated otherwise dormant functions of Schwann cells aimed at nerve regeneration and wound healing. Such reprogramming of Schwann cells into repair-like cells occurred during the destruction and displacement of neurons as the tumor expanded and via direct signaling from melanoma cells to Schwann cells, resulting in activation of the nerve injury response. Melanoma-activated Schwann

SUBMITTER: Shurin GV 

PROVIDER: S-EPMC6522315 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature