The formation of all-cis-(multi)fluorinated piperidines by a dearomatization-hydrogenation process.

ABSTRACT: Piperidines and fluorine substituents are both independently indispensable components in pharmaceuticals, agrochemicals and materials. Logically, the incorporation of fluorine atoms into piperidine scaffolds is therefore an area of tremendous potential. However, synthetic approaches towards the formation of these architectures are often impractical. The diastereoselective synthesis of substituted monofluorinated piperidines often requires substrates with pre-defined stereochemistry. That of multifluorinated piperidines is even more challenging, and often needs to be carried out in multistep syntheses. In this report, we describe a straightforward process for the one-pot rhodium-catalysed dearomatization-hydrogenation of fluoropyridine precursors. This strategy enables the formation of a pl

SUBMITTER: Nairoukh Z 

PROVIDER: S-EPMC6522351 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature