Measurement of Tumor Antioxidant Capacity and Prediction of Chemotherapy Resistance in Preclinical Models of Ovarian Cancer by Positron Emission Tomography.

ABSTRACT:

Purpose

Drug resistance is a major obstacle for the effective treatment of patients with high-grade serous ovarian cancer (HGSOC). Currently, there is no satisfactory way to identify patients with HGSOC that are refractive to the standard of care. Here, we propose the system x_c ^- radiotracer (4S)-4-(3-[¹⁸F]fluoropropyl)-l-glutamate ([¹⁸F]FSPG) as a non-invasive method to measure upregulated antioxidant pathways present in drug-resistant HGSOC.

Experimental design

Using matched chemotherapy sensitive and resistant ovarian cancer cell lines, we assessed their antioxidant capacity and its relation to [¹⁸F]FSPG uptake, both in cells and in animal models of human ovarian cancer. We identified the mechanisms driving dif

SUBMITTER: Greenwood HE 

PROVIDER: S-EPMC6522377 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature