Historical Changes in Histological Diagnosis of Lung Cancer.

ABSTRACT:

Background

Histological classification of lung cancer is essential for investigations of carcinogenesis and treatment selection. We examined the temporal changes of lung cancer histological subtypes.

Methods

Lung cancer cases diagnosed in the Life Span Study cohort between 1958 and 1999 were collected from tumor registries (TR), mainly consisting of population-based cancer registries. A total of 1,025 cases were histologically reviewed according to the World Health Organization 2004 Classification by a panel of pathologists (PP). Sensitivity and specificity of diagnoses in TR were calculated, assuming that the diagnosis by PP was the gold standard.

Results

Sensitivity and specificity were 0.91 and 0.92 for adenocarcinoma (AD), respectively, and 0.92 and 0.94, respecti

SUBMITTER: Utada M 

PROVIDER: S-EPMC6522388 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature