Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer.

ABSTRACT:

Background

Reversible N⁶-methyladenosine (m⁶A) modifications in messenger RNAs can be categorized under the field of "RNA epigenetics." However, the potential role of m⁶A-related genes in gastric cancer (GC) prognosis has not been systematically researched.

Aims

This study was aimed at providing insights into the prognostic role of m⁶A-related gene expression, at both mRNA and protein levels.

Methods

Kaplan-Meier (KM) plotter database and The Cancer Genome Atlas (TCGA) database were used to explore the prognostic significance of individual m⁶A-related genes in overall survival (OS) and progression-free survival at the mRNA level. For independent validation, the protein level of genes significantly associated with

SUBMITTER: Li Y 

PROVIDER: S-EPMC6522448 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature