Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide ⁴⁷Sc.

ABSTRACT:

Background

In molecular imaging and nuclear medicine, theranostic agents that integrate radionuclide pairs are successfully being used for individualized care, which has led to rapidly growing interest in their continued development. These compounds, which are radiolabeled with one radionuclide for imaging and a chemically identical or similar radionuclide for therapy, may improve patient-specific treatment and outcomes by matching the properties of different radionuclides with a targeting vector for a particular tumor type. One proposed theranostic radionuclide is scandium-47 (⁴⁷Sc, T_1/2 = 3.35 days), which can be used for targeted radiotherapy and may be paired with the positron emitting radionuclides, ⁴³Sc (T_1/2 = 3.89 h) and ^44</

SUBMITTER: Loveless CS 

PROVIDER: S-EPMC6522578 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature