Comparison of desferrioxamine and NODAGA for the gallium-68 labeling of exendin-4.

ABSTRACT:

Introduction

Radiolabeled exendin-4 (Ex4) derivatives are used to target the glucagon-like peptide-1 receptor (GLP-1R) for the clinical diagnosis of insulinomas, a rare type of neuroendocrine tumor. Gallium-68 is an ideal diagnostic nuclide for this application and a study evaluating an exendin-4-NODAGA conjugate is currently underway. However, in complexion with the chelator DFO, its in vivo stability has been a matter of dispute. The aim of this work was to directly compare [⁶⁸Ga]Ga-Ex4NOD with [⁶⁸Ga]Ga-Ex4DFO in vitro and in vivo.

Methods

In our approach, we directly compared N'-[5-(acetyl-hydroxy-amino)pentyl]-N-[5-[3-(5-aminopentyl-hydroxy-carbamoyl)propanoylamino]pentyl]-N-hydroxy-butane diamide (desferriox-amine B, DFO) and 2-(4,7-bis (carboxymet

SUBMITTER: Kaeppeli SAM 

PROVIDER: S-EPMC6522624 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature