Long-acting Opioid Use and the Risk of Serious Infections: A Retrospective Cohort Study.

ABSTRACT:

Background

Although evidence from animal and human studies indicates opioid analgesics increase susceptibility to infections, it is unclear whether the risk varies by specific opioid. We compared the risk of serious infection among patients initiating long-acting opioid analgesics with and without previously reported immunosuppressive properties.

Methods

We conducted a retrospective cohort study of Tennessee Medicaid enrollees age ≥18 years initiating long-acting opioids (1995-2015). Hospitalizations for serious infection were identified using validated coding algorithms. We used multivariable Poisson regression models to calculate adjusted incidence rate ratios (aIRR) and 95% confidence intervals (CI) to compare the infection risk among patients using long-acting opioids wi

SUBMITTER: Wiese AD 

PROVIDER: S-EPMC6522680 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature