Associations between cytotoxic T-lymphocyte-associated antigen 4 gene polymorphisms and diabetes mellitus: a meta-analysis of 76 case-control studies.

ABSTRACT: Background: Several genetic association studies already investigated potential roles of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms in diabetes mellitus (DM), with inconsistent results. Therefore, we performed this meta-analysis to better assess the relationship between CTLA-4 gene polymorphisms and DM in a larger pooled population.Methods: PubMed, Embase, Web of Science, and CNKI were systematically searched for eligible studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of associations between CTLA-4 gene polymorphisms and DM in all possible genetic models.Results: A total of 76 studies were finally included in our analyses. Significant associations with susceptibility to type 1 diabetes mellitus (T1D

SUBMITTER: Chen M 

PROVIDER: S-EPMC6522704 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature