Pristimerin inhibits glioma progression by targeting AGO2 and PTPN1 expression via miR-542-5p.

ABSTRACT: Glioblastoma multiform is the most common and malignant primary tumor of the central nervous system in adults, the high recurrence rate and poor prognosis are critical priorities. Pristimerin is a naturally occurring quinone methide triterpenoid isolated from the Celastraceae and Hippocrateaceae families. Its anticancer effects have garnered considerable attention; nonetheless, the mechanisms of action remain unknown. To predict the hub genes of pristimerin, PharmMapper and the Coremine database were used to identify 13 potential protein targets; protein-protein interaction, for which functional enrichment analyses were performed. Compound-target, target-pathway, and compound-target-pathway networks were constructed using Cytoscape. Biological process analysis first revealed that enrichmen

SUBMITTER: Li Z 

PROVIDER: S-EPMC6522714 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature