Iron Status and Associated Malaria Risk Among African Children.

ABSTRACT:

Background

It remains unclear whether improving iron status increases malaria risk, and few studies have looked at the effect of host iron status on subsequent malaria infection. We therefore aimed to determine whether a child's iron status influences their subsequent risk of malaria infection in sub-Saharan Africa.

Methods

We assayed iron and inflammatory biomarkers from community-based cohorts of 1309 Kenyan and 1374 Ugandan children aged 0-7 years and conducted prospective surveillance for episodes of malaria. Poisson regression models were fitted to determine the effect of iron status on the incidence rate ratio (IRR) of malaria using longitudinal data covering a period of 6 months. Models were adjusted for age, sex, parasitemia, inflammation, and study site.

Results<

SUBMITTER: Muriuki JM 

PROVIDER: S-EPMC6522755 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature