Structural and functional impact of non-synonymous SNPs in the CST complex subunit TEN1: structural genomics approach.

ABSTRACT: TEN1 protein is a key component of CST complex, implicated in maintaining the telomere homeostasis, and provides stability to the eukaryotic genome. Mutations in TEN1 gene have higher chances of deleterious impact; thus, interpreting the number of mutations and their consequential impact on the structure, stability, and function is essentially important. Here, we have investigated the structural and functional consequences of nsSNPs in the TEN1 gene. A wide array of sequence- and structure-based computational prediction tools were employed to identify the effects of 78 nsSNPs on the structure and function of TEN1 protein and to identify the deleterious nsSNPs. These deleterious or destabilizing nsSNPs are scattered throughout the structure of TEN1. However, major mutations we

SUBMITTER: Amir M 

PROVIDER: S-EPMC6522806 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature