Clinical significance of miRNA‑1 and its potential target gene network in lung squamous cell carcinoma.

ABSTRACT: Previous studies demonstrated that miRNA‑1 (miR‑1) is downregulated in certain human cancer and serves a crucial role in the progression of cancer. However, there are only a few previous studies examining the association between miR‑1 and lung squamous cell carcinoma (LUSC) and the regulatory mechanism of miR‑1 in LUSC remains unclear. Therefore, the present study investigated the clinical significance and determined the potential molecular mechanism of miR‑1 in LUSC. The expression of miR‑1 and its clinical significance in LUSC was examined by conducting a meta‑analysis of 12 studies using Stata 14, MetaDiSc1.4 and SPSS version 23. In addition, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed using the potential target genes of miR‑1 gat

SUBMITTER: Li X 

PROVIDER: S-EPMC6522896 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature