Titin-truncating variants are associated with heart failure events in patients with left ventricular non-compaction cardiomyopathy.

ABSTRACT:

Background

Titin-truncating variants (TTNtv) have been recognized as the most prevalent genetic cause of dilated cardiomyopathy. However, their effects on phenotypes of left ventricular non-compaction cardiomyopathy (LVNC) remain largely unknown.

Hypothesis

The presence of TTNtv may have an effect on the phenotype of LVNC.

Methods

TTN was comprehensively screened by targeted sequencing in a cohort of 83 adult patients with LVNC. Baseline and follow-up data of all participants were collected. The primary endpoint was a composite of death and heart transplantation. The secondary endpoint was heart failure (HF) events, a composite of HF-related death, heart transplantation, and HF hospitalization.

Results

Overall, 13 TTNtv were identified in 13 patients, with 9 TT

SUBMITTER: Li S 

PROVIDER: S-EPMC6523007 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature