Injectable Alginate-Peptide Composite Hydrogel as a Scaffold for Bone Tissue Regeneration.

ABSTRACT: The high demand for tissue engineering scaffolds capable of inducing bone regeneration using minimally invasive techniques prompts the need for the development of new biomaterials. Herein, we investigate the ability of Alginate incorporated with the fluorenylmethoxycarbonyl-diphenylalanine (FmocFF) peptide composite hydrogel to serve as a potential biomaterial for bone regeneration. We demonstrate that the incorporation of the self-assembling peptide, FmocFF, in sodium alginate leads to the production of a rigid, yet injectable, hydrogel without the addition of cross-linking agents. Scanning electron microscopy reveals a nanofibrous structure which mimics the natural bone extracellular matrix. The formed composite hydrogel exhibits thixotropic behavior and a high storage modulus of approxi

SUBMITTER: Ghosh M 

PROVIDER: S-EPMC6523611 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature