Gut Microbiota Shifts in Pup Athymic BALB/c Mice: An Updated Identification in Nude Mice.

ABSTRACT: It is commonly recognized that immunodeficiency modifies the gut microbiota in mammals. However, little information on the gut microbiota is available for athymic nude mice; one of the most popular animals for modeling immunodeficiency and tumors. In this study, 16S rDNA amplicon sequencing was performed to investigate the gut microbial composition of pup nude BALB/c mice during a 30-day experimental period. In contrast to pup normal mice, pup nude mice showed a significant variation in gut microbiota. Continuously decreased dynamics of the gut bacterial Shannon index, abnormal Firmicutes/Bacteroidetes ratio, the rarity of Bifidobacterium and Lactobacillus species, and a developmental lag of gut bacterial functions were observed in nude mice. The shift in gut microbiota and abnormal coloni

SUBMITTER: Li Y 

PROVIDER: S-EPMC6523615 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature