Leptin Promotes White Adipocyte Browning by Inhibiting the Hh Signaling Pathway.

ABSTRACT: Leptin is an important secretory protein that regulates the body's intake and energy consumption, and the functions of the Hh signaling pathway related to white adipocyte browning are controversial. It has been reported that leptin plays a critical role in adipogenesis by regulating the Hh signaling pathway, but whether there is a functional relationship between leptin, the Hh signaling pathway, and adipocyte browning is not clear. In this research, mouse white pre-adipocytes were isolated to explore the influence of the Hh signal pathway and leptin during the process described above. This showed that leptin decreased high fat diet-induced obese mice body weight and inhibited the Hh signaling pathway, which suggested that leptin and the Hh signaling pathway have an important role in obesit

SUBMITTER: Wang J 

PROVIDER: S-EPMC6523697 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature