Hepatitis C Virus Infection: Host⁻Virus Interaction and Mechanisms of Viral Persistence.

ABSTRACT: Hepatitis C (HCV) is a major cause of liver disease, in which a third of individuals with chronic HCV infections may develop liver cirrhosis. In a chronic HCV infection, host immune factors along with the actions of HCV proteins that promote viral persistence and dysregulation of the immune system have an impact on immunopathogenesis of HCV-induced hepatitis. The genome of HCV encodes a single polyprotein, which is translated and processed into structural and nonstructural proteins. These HCV proteins are the target of the innate and adaptive immune system of the host. Retinoic acid-inducible gene-I (RIG-I)-like receptors and Toll-like receptors are the main pattern recognition receptors that recognize HCV pathogen-associated molecular patterns. This interaction results in a downstream cas

SUBMITTER: Chigbu DI 

PROVIDER: S-EPMC6523734 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature