How Often Do Protein Genes Navigate Valleys of Low Fitness?

ABSTRACT: To escape from local fitness peaks, a population must navigate across valleys of low fitness. How these transitions occur, and what role they play in adaptation, have been subjects of active interest in evolutionary genetics for almost a century. However, to our knowledge, this problem has never been addressed directly by considering the evolution of a gene, or group of genes, as a whole, including the complex effects of fitness interactions among multiple loci. Here, we use a precise model of protein fitness to compute the probability P ( s , Δ t ) that an allele, randomly sampled from a population at time t, has crossed a fitness valley of depth s during an interval t - Δ t , t in the immediate past. We study populations of model genes evolving under equilibrium conditions consistent wit

SUBMITTER: Nelson ED 

PROVIDER: S-EPMC6523826 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature