Effect of Electrospun Fiber Mat Thickness and Support Method on Cell Morphology.

ABSTRACT: Electrospun fiber mats (EFMs) are highly versatile biomaterials used in a myriad of biomedical applications. Whereas some facets of EFMs are well studied and can be highly tuned (e.g., pore size, fiber diameter, etc.), other features are under characterized. For example, although substrate mechanics have been explored by several groups, most studies rely on Young's modulus alone as a characterization variable. The influence of fiber mat thickness and the effect of supports are variables that are often not considered when evaluating cell-mechanical response. To assay the role of these features in EFM scaffold design and to improve understanding of scaffold mechanical properties, we designed EFM scaffolds with varying thickness (50-200 µm) and supporting methodologies. EFM scaffolds were com

SUBMITTER: Calhoun MA 

PROVIDER: S-EPMC6523829 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature