Glutathione S-transferase theta genotypes and environmental exposures in the risk of canine transitional cell carcinoma.

ABSTRACT:

Introduction

Transitional cell carcinoma (TCC) in humans is associated with environmental exposures and variants in glutathione S-transferase (GST) genes. Scottish Terriers have a high breed risk for TCC, but the relationship between genetic and environmental risk in dogs is not fully understood.

Hypotheses

Scottish Terriers have a higher frequency of GST-theta variants compared to lower risk breeds. Dogs with TCC of any breed have a higher frequency of GST-theta variants along with higher environmental exposures, compared to controls.

Animals

One hundred and five Scottish Terriers and 68 controls from lower risk breeds; 69 dogs of various breeds with TCC, and 72 breed- and sex-matched unaffected geriatric dogs.

Methods

In this prospective case-control study, d

SUBMITTER: Luethcke KR 

PROVIDER: S-EPMC6524089 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature