Untargeted metabolomic profiling of serum from dogs with chronic hepatic disease.

ABSTRACT:

Background

Chronic hepatopathies present a diagnostic challenge, with different diseases being associated with similar clinical and laboratory findings. Characterization of dogs with chronic hepatopathies can be difficult and require costly diagnostic procedures such as acquisition of a liver biopsy specimen. Noninvasive and inexpensive biomarkers that reliably characterize chronic hepatopathies such as chronic hepatitis or a congenital portosystemic vascular anomaly may decrease the need for costly or invasive diagnostic testing and guide novel therapeutic interventions.

Objective

To investigate differences in the serum metabolome among healthy dogs, dogs with congenital portosystemic shunts, and dogs with chronic hepatitis.

Animals

Stored serum samples from 12 healt

SUBMITTER: Lawrence YA 

PROVIDER: S-EPMC6524095 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature