Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers.

ABSTRACT: The release profiles of methotrexate, an anticancer drug, from the monoolein liquid crystalline cubic phases were studied. The cubic phases were used either in the form of a lipidic film deposited onto a glassy carbon electrode surface or in the dispersed form of magnetocubosomes, which are considered a prospective hybrid drug delivery system. Commonly, cubosomes or liposomes are employed, but not in the case of toxic methotrexate, known to block the receptors responsible for folate transport into the cells. The release profiles of the drug from the lipidic films were monitored electrochemically and described using the Higuchi model. They were also modified via changes in temperature; the release was faster, although it deviated from the model when the temperature was increased. Cubic phas

SUBMITTER: Mierzwa M 

PROVIDER: S-EPMC6524136 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature