Rapid reviews may produce different results to systematic reviews: a meta-epidemiological study.

ABSTRACT:

Objective

To simulate possible changes in systematic review results if rapid review methods were used.

Study design and setting

We recalculated meta-analyses for binary primary outcomes in Cochrane systematic reviews, simulating rapid review methods. We simulated searching only PubMed, excluding older articles (5, 7, 10, 15, and 20 years before the search date), excluding smaller trials (<50, <100, and <200 participants), and using the largest trial only. We examined percentage changes in pooled odds ratios (ORs) (classed as no important change [<5%], small [<20%], moderate [<30%], or large [≥30%]), statistical significance, and biases observed using rapid methods.

Results

Two thousand five hundred and twelve systematic reviews (16,088 studies) were included. Rapid me

SUBMITTER: Marshall IJ 

PROVIDER: S-EPMC6524137 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature