Correcting for misclassification and selection effects in estimating net survival in clinical trials.

ABSTRACT:

Background

Net survival, a measure of the survival where the patients would only die from the cancer under study, may be compared between treatment groups using either "cause-specific methods", when the causes of death are known and accurate, or "population-based methods", when the causes are missing or inaccurate. The latter methods rely on the assumption that mortality due to other causes than cancer is the same as the expected mortality in the general population with same demographic characteristics derived from population life tables. This assumption may not hold in clinical trials where patients are likely to be quite different from the general population due to some criteria for patient selection.

Methods

In this work, we propose and assess the performance of a new fle

SUBMITTER: Goungounga JA 

PROVIDER: S-EPMC6524224 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature