MiR-107 function as a tumor suppressor gene in colorectal cancer by targeting transferrin receptor 1.

ABSTRACT:

Background

While microRNAs (miRNAs) are known to play a critical role in the progression of colorectal cancer, the role of miR-107 remains unknown. We evaluated its role and explored the underlying mechanism.

Materials & methods

MTT, wound-healing, transwell migration and transwell invasion assays were performed to evaluate the role of miR-107 in SW629 cell proliferation, migration and invasion. Real time-PCR and dual-luciferase reporter gene, TFR1 overexpression and western blotting assays were used to explore the underlying mechanism.

Results

MiR-107 is downregulated in colorectal cancer tissues and several human colorectal cancer cell lines. Low miR-107 expression often indicates a poor survival rate for colorectal cancer patients. MiR-107 suppresses the proliferat

SUBMITTER: Fu Y 

PROVIDER: S-EPMC6524234 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature