Subsequent thyroid disorders associated with treatment strategy in head and neck cancer patients: a nationwide cohort study.

ABSTRACT:

Background

We investigated the risk of thyroid disorders, namely hypothyroidism, thyrotoxicosis and thyroiditis, in head and neck cancer patients undergoing multimodal treatment.

Methods

A cohort study design using Taiwan's National Health Insurance Research Database was used to assess head and neck cancer patients over 20 years old. The cohort was divided into one group who underwent primary tumor excision only (PTE) and another with additional neck dissection (PTE + ND). The tumor sites were stratified to estimate the tumor-site-specific risk of thyroid disorders. The effect of subsequent resurgery, radiotherapy (RT), chemotherapy (CT), and concomitant (CCRT) or sequential chemoradiation therapy (sequential CT+ RT) on the risk of thyroid disorders was explored.

Results<

SUBMITTER: Lin CL 

PROVIDER: S-EPMC6524259 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature