Spontaneous virus reactivation in cattle chronically infected with bovine leukemia virus.

ABSTRACT:

Background

The absence of virus expression during the chronic stage of bovine leukemia virus (BLV) infection and its reactivation upon ex vivo culture has become a long-lived Dogma. During the chronic stage of BLV infection the immune response limits viral replication and the mitotic division of latently infected cells, carrying BLV provirus, allows viral expansion and disease progression towards a lymphoproliferative disorder. Several stressor factors have been associated with animal production and handling. As natural mediator of stress, glucocorticoids are strong immunosuppressive agents; moreover, they can bind long-terminal repeat region of retroviruses and induce viral expression. In the present study, we present a case report describing the spontaneous reactivation of BLV in

SUBMITTER: Jaworski JP 

PROVIDER: S-EPMC6524309 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature