Mechanical dilation, botulinum toxin A injection, and surgical myotomy with fundoplication for treatment of lower esophageal sphincter achalasia-like syndrome in dogs.

ABSTRACT:

Background

Megaesophagus (ME) carries a poor long-term prognosis in dogs. In people, lower esophageal sphincter (LES) achalasia is a rare cause of ME that may respond to targeted intervention. Dogs with lower esophageal sphincter achalasia-like syndrome (LES-AS) have been described recently, warranting investigation of analogous targeted treatment.

Hypothesis/objectives

Evaluate response of dogs with LES-AS to LES mechanical dilation and botulinum toxin A (BTA) injections, with or without surgical myotomy and fundoplication. We hypothesized that clinical and videofluoroscopic swallow study (VFSS) features of LES-AS would improve after treatment targeting functional LES obstruction.

Animals

Fourteen client-owned dogs with LES-AS diagnosed by VFSS.

Methods

Retros

SUBMITTER: Grobman ME 

PROVIDER: S-EPMC6524387 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature