Nanofibrous Scaffolds Support a 3D in vitro Permeability Model of the Human Intestinal Epithelium.

ABSTRACT: Advances in drug research not only depend on high throughput screening to evaluate large numbers of lead compounds but also on the development of in vitro models which can simulate human tissues in terms of drug permeability and functions. Potential failures, such as poor permeability or interaction with efflux drug transporters, can be identified in epithelial Caco-2 monolayer models and can impact a drug candidate's progression onto the next stages of the drug development process. Whilst monolayer models demonstrate reasonably good prediction of in vivo permeability for some compounds, more developed in vitro tools are needed to assess new entities that enable closer in vivo in vitro correlation. In this study, an in vitro model of the human intestinal

SUBMITTER: Patient JD 

PROVIDER: S-EPMC6524416 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature