Association between iscR-based phylogeny, serovars and potential virulence markers of Haemophilus parasuis.

ABSTRACT: Haemophilus parasuis is an economically important bacterial pathogen of swine. Extensive genetic and phenotypic heterogeneity among H. parasuis strains have been observed, which hinders the deciphering of the population structure and its association with clinical virulence. In this study, two highly divergent clades were defined according to iron-sulphur cluster regulator (iscR)-based phylogeny analysis of 148 isolates. Clear separation of serovars and potential virulence markers (PVMs) were observed between the two clades, which are indicative of independent evolution of the two lineages. Previously suggested virulence factors showed no correlation with clinical virulence, and were probably clade or serovar specific genes emerged during different stage of evolution. P

SUBMITTER: Li J 

PROVIDER: S-EPMC6524630 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature