Cell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System.

ABSTRACT: Dorsal closure is a key process during Drosophila morphogenesis that models cell sheet movements in chordates, including neural tube closure, palate formation, and wound healing. Closure occurs midway through embryogenesis and entails circumferential elongation of lateral epidermal cell sheets that close a dorsal hole filled with amnioserosa cells. Signaling pathways regulate the function of cellular structures and processes, including Actomyosin and microtubule cytoskeletons, cell-cell/cell-matrix adhesion complexes, and endocytosis/vesicle trafficking. These orchestrate complex shape changes and movements that entail interactions between five distinct cell types. Genetic and laser perturbation studies establish that closure is robust, resilient, and the consequence of redundancy that con

SUBMITTER: Kiehart DP 

PROVIDER: S-EPMC6524656 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature