Ontology highlight
ABSTRACT:
SUBMITTER: Yagi M
PROVIDER: S-EPMC6524733 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Stem cell reports 20190502 5
CpG islands (CGIs) including those at imprinting control regions (ICRs) are protected from de novo methylation in somatic cells. However, many cancers often exhibit CGI hypermethylation, implying that the machinery is impaired in cancer cells. Here, we conducted a comprehensive analysis of CGI methylation during somatic cell reprogramming. Although most CGIs remain hypomethylated, a small subset of CGIs, particularly at several ICRs, was often de novo methylated in reprogrammed pluripotent stem ...[more]